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For example, in cultured endothelial cells, lipoic acid was found to inhibit IKK-, an enzyme that promotes the translocation of redox-sensitive and pro-inflammatory transcription factor, nuclear factor-kappa B (NFB) from the cytosol to the nucleus (46)

Concomitantly, we measured increased pyruvate levels in mutant compared to control cells (Supplementary Fig

Less common effects: Nausea or mild stomach discomfort

The fact that we observe autoproteolytic processing after deacetylation of wild type SnCE1 by SIRT1 suggests acetylation at enzymatically accessible sites in the N-terminal region, i.e., Lys78, Lys94 and Lys98, to regulate autoproteolysis in cells rather than acetylation at Lys209 and Lys248 as these were not deacetylated by SIRT1 (Supplementary Fig