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In animal models, this is the window over which metabolic and adipocyte changes accumulate

The second is dose and route translation : even where an effect is real in a mouse, the human-equivalent dose is not a simple body-weight scaling, and as the route section above stressed there is no human bioavailability figure to anchor an oral-versus-injected comparison

Intestinal absorption of dietary iron increases during the second and third trimesters, yet many women still develop iron deficiency or iron-deficiency anemia during pregnancy

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