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The activation of mTOR leads to the phosphorylation of eukaryotic translation initiation factor 4E-binding protein (4E-BP), increased recruitment of eukaryotic translation initiation factor 4E (eIF4E), and initiation of protein translation [81]

Owing to their unique physicochemical and functional properties, metal nanomedicines display enormous potential in a variety of anticancer applications, such as selective drug delivery, tumor microenvironment (TME) regulation, and combination therapy against cancer (Sharma et al., 2015