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where available, cite modelspecific data to support claims

QSSA was used in this iteration of the design to assume enzyme levels stayed constant, but further investigation of the induction of oxidative stress genes by ROS and how this might change enzyme concentrations would be of value

Bibcode:2000BBRC..269..366K

These non-genomic signals are mediated by membrane-associated receptors and can rapidly activate pathways such as extracellular signal-regulated kinase)/mitogen-activated protein kinase, protein kinase C (elevating intracellular Ca 2+ ), JNK/phosphatidylinositol 3 kinase, and cAMP-dependent transcription, which regulate critical cellular processes including apoptosis