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B12 deficiency is frequently observed in individuals with long-term NSAID use, likely related to gastric irritation that affects absorption

After dosing, blood samples were collected as follows (times and blood volumes collected are listed in chronological order): After each blood sample was taken, the catheter was flushed with saline solution and a volume of saline equal to the volume of blood taken was injected (to maintain total blood volume)

Other supplements that provide the body extra amounts of the building blocks it requires to make these natural antioxidants, such as manganese, zinc, copper, and selenium, may also be an effective way to increase their presence in the body

As a typical example, Yang et al