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Remember, however, there is no good scientific evidence that milk thistle benefits liver health

Not only does the remethylation of homocysteine contribute to methyl group synthesis, but it also serves as a means to prevent the intracellular accumulation of S-adenosylhomocysteine and an increase in plasma total homocysteine levels [14, 20, 21, 22]

Its inclusion in the Category 2 restricted list has drawn criticism from clinicians who point to its legitimate international approval record as evidence that the safety concerns cited by the FDA are inconsistent with the global clinical literature

Self-directed therapy without appropriate medical supervision may result in adverse outcomes and is strongly discouraged