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You should know exactly what is (and isn't) in the bottle

IGF-1 LR3 For In Vitro Research Use Only Not for Human or Veterinary Application For In Vitro Research Use Only Not for Human or Veterinary Application IGF-1 LR3 (Long Arg3 Insulin-like Growth Factor-1) is a synthetic 83-amino acid analog of native insulin-like growth factor-1 (IGF-1), incorporating a 13-amino acid N-terminal extension and a substitution of arginine for glutamic acid at position 3 of the mature IGF-1 sequence

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Multiple clinical trials show improvements in wrinkle depth, skin elasticity, and UV-induced damage after 612 weeks of supplementation (Tominaga et al., 2012, Acta Biochimica Polonica )