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Over time, the reduction in melanin production leads to lighter skin with fewer dark spots and uneven pigmentation

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Aberrant lipid metabolism in HCC generally manifests as alternations in lipid uptake and efflux, dysregulated endogenous lipid synthesis, elevated cholesterol esterification, and disruptions in lipid oxidation

Materials and methods Animals and experimental design Nine-week-old male Fischer 344 rats (Charles River Laboratory, Japan), weighing from 180-200 g, were maintained at 23C, given standard laboratory chow and water ad libitum, and kept under a 12 h light (7:00-19:00)/12 h dark schedule