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Current thoughts on the use of metformin for longevity [1:21:00]

see Figure 1 ) are excreted by the kidneys

Chem Res Toxicol 25:16161632 Brink A et al (2017) Minimizing the risk of chemically reactive metabolite formation of new drug candidates: implications for preclinical drug design

[19] [20] More serious but rare risks include pancreatitis (severe abdominal pain radiating to the back), gallbladder disease (right upper quadrant pain, fever, jaundice), and potential thyroid C-cell tumors (based on animal data)