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Chronically elevated insulin levels may affect inner ear blood flow, disrupting the complex chemical balance of inner ear fluids and resulting in vestibular dysfunction

Oncometabolites drive tumorigenesis by enhancing protein acylation: from chromosomal remodelling to nonhistone modification

Methods Experimental model and details Animal studies All animal studies were performed according to protocols approved by the University Committee on Animal Resources at the University of Rochester Medical Center

Our results, demonstrating the downregulation of the core apoptotic executioners Caspase-3 and Caspase-8, consolidate and extend reports of its anti-apoptotic activity across various models, such as the inhibition of Caspase-3/9 in diabetic retinopathy 81,82 , The suppression of apoptosis via Akt pathway activation in kidney injury, and the regulation of BAX/BCL-2/CASPASE-3/8 balance during viral infection 83,84