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This observation is in line with (a) decreased plasma GSH levels in women who underwent surgical menopause (Kaur et al., 2017), and (b) decreased serum tGSH levels in post- relative to pre-menopausal women (Ramrez-Expsito et al., 2014)

However, this does not explain the fact that, in the ER, the ratio of reduced to oxidized glutathione ([GSH]:[GSSG]) is optimal for disulphidebond formation (Lyles & Gilbert, 1991)

Laboratory data showed that S-acetyl glutathione increased intracellular glutathione and had a positive effect on many oxidative stress biomarkers

It helps remove reactive oxygen species, supports detoxification, and works as a substrate for glutathione peroxidase enzymes