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1 Introduction Chronic kidney disease (CKD) represents a growing global health burden, with increasing mortality and disability-adjusted life years (DALYs) ( 2 Vitamin D metabolism and physiological functions Vitamin D is a fat-soluble prohormone that is synthesized primarily in the skin from 7-dehydrocholesterol under ultraviolet B (UVB) radiation, forming previtamin D, which is then thermally isomerized into cholecalciferol (vitamin D)

This concentration supports multiple goals at once, including relaxing the look of strong expression lines, tightening the appearance of loose skin by supporting collagen and elastin, and improving overall skin clarity

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However, how quickly you see these results depends on how you take B12