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Teratani T, et al

The N-terminal periplasmic domains also interact with the components of the cytoplasmic membrane-embedded platform of the secretion machinery, to promote channel opening, cargo docking, and subsequent release 26,27

Since mitochondria need oxygen to burn fat, it follows that supplementation with carnitine ensures an adequate supply of oxygen to the muscle

Additionally, although the thiolactone form has not been unequivocally identified in vivo , homocysteine could undergo intracellular cyclization into homocysteine thiolactone, which could be a major by-product of impaired homocysteine metabolism (Jakubowski, 1997