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Thus, on top of the direct beneficial effects of ketone bodies including antioxidative and anti-inflammatory functions (discussed in [169,170]), IF (but also very-low-carbohydrate-diets) could reverse this so-called ketogenic insufficiency that has been observed in NAFLD [171] by increasing hydrolysis of IHLC partitioning fatty acids towards ketogenesis, thereby improving mitochondrial redox state [20]

Targeted lifestyle changes, evidence-backed supplements, and personalized GLP-1 medications can be just as effective

Flavonoids, in combination with omega-3 fatty acids, ameliorated muscle and cardiac damage in a Duchenne muscular dystrophy (DMD) animal model (Tripodi et al

Initially developed for obesity treatment, AOD9604 showed weight-reducing effects in rodent models comparable to those of full-length GH, but without inducing diabetes or stimulating IGF-1 production