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In particular, the initial burst of superoxide that cannot be eliminated efficiently due to the inactivity of SOD1 is promptly buffered by the induction of GSH synthesis resulting in protection against oxidative stress and cell death

People who lack proper glutathione production face several health problems, from red blood cell breakdown to gradual mental decline

SP600125, a classical ATP-competitive inhibitor of JNK, has been reported to have protective effects against AIH in vivo and in vitro

Statements Acknowledgments We apologize for not being able to cite many relevant original papers, replaced by reviews, due to space limitation