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Human MTHFR consists of an N-terminal catalytic domain (amino acids 1356) which binds 5,10-methylenetetrahydrofolate (5,10-methylene THF), and a C-terminal regulatory domain (amino acids 363656) which binds S-adenosylmethionine (AdoMet, SAM) 16,17
Both prophylactic and therapeutic administration of Cur-NLCs effectively counteracted A-mediated cognitive dysfunction and neuronal toxicity, demonstrating their robust neuroprotective activity (146)
Arosio, E., De Marchi, S., Zannoni, M., Prior, M., & Lechi, A
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