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Mitochondria are the primary source of intracellular ROS, and ROS modulator 1 is one of the key mitochondrial proteins involved in ROS production 36

Interestingly, it has been found that DSIP can modulate the levels of serotonin and its metabolites, thus playing a potential role in treating depression (6)

Weight loss of 7-10% of body weight remains the most evidence-based intervention for improving liver health in NAFLD, as emphasised in NICE guidance

Patients with IBS can be categorized into four major subtypes depending on the predominant stool pattern, including IBS with constipation (IBS-C), IBS with diarrhea (IBS-D), IBS with mixed bowel habits (IBS-M) and unclassified IBS (Lacy et al., 2016)