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While UK healthcare professionals can, in exceptional circumstances, prescribe unlicensed medicines under the MHRA 'specials' framework, this would rarely be appropriate for ED given the availability of licensed, evidence-based alternatives

These findings suggest that the GCGR agonism of Retatrutide contributes to the reduction in circulating ANGPTL3/8, which in turn may lead to lower triglyceride and LDL-cholesterol levels

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In patients receiving cagrilintide 2.4 mg plus semaglutide, there was a mean body weight change from baseline of -17.1% compared to -9.8% with semaglutide alone