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Neuss MN, Polovich M, McNiff K, Esper P, Gilmore TR, LeFebvre KB,

3 Mechanisms of action of natural supplements against breast cancer 3.1 Anti-inflammatory and antioxidant pathways The chronic inflammatory microenvironment in the breast activates nuclear factor-B (NF-B), cyclooxygenase-2 (COX-2), signalling transducers and activators of transcription-3 (STAT3), activator protein-1, and mitogen-activated protein kinase signalling cascades

RCAN1 depletion restores the mitochondrial network, together with oxygen consumption, indicating that the increased dosage of RCAN1 is responsible for the alteration of mitochondrial dynamics in the context of DS

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