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Rahman et al., 1996

Early clinical studies on the use of new predictive biomarkers in chronic and acute leukemias, colon cancer, breast cancer, non-small cell lung cancer, and melanoma have shown promising results (Eustace 2014

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The slow intravenous infusion protocols used in clinical trials minimized these effects, suggesting that rapid bolus administration (which is essentially what subcutaneous injection creates) may increase the likelihood of transient side effects