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Notably, no significant changes in bone turnover markers (osteocalcin, bone-specific alkaline phosphatase) were observed, indicating effects primarily through bone volume rather than remodeling markers

doi: 10.1210/clinem/dgae070 143 TollABlanco-HinojoLBergeDManzanoAEl AbidiKPerez-SolVet al

Clinically, these insights suggest that routine metabolic profilingespecially of carnitine-acylcarnitine pathwayscould serve as a valuable adjunct in assessing treatment response and guiding individualized therapy