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This reinstates the detection and destruction of tumor cells, preventing them from evading the immune response [110]

Noting that it is off label for patients without diabetes, pioglitazone is suggested by a number of guidelines as a possible treatment for patients with NASH or advanced fibrosis [12, 14, 17, 43, 45, 46]

This indicates that lipid desaturation could serve as a potential biomarker for identifying OCSCs (93)

Acknowledgements This research was supported by the Arkansas Biosciences Institute (Little Rock, AR, USA), The Jonty Foundation (St Paul, MN), The Autism Research Institute (San Diego, CA), the Gupta Family Foundation (Atherton, CA), The Jane Bostford Johnson Foundation (New York, NY) and the Jager Family Foundation (Chicago, IL)