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This is due to damage to the gastrointestinal system that limits their B12 absorption and genetic polymorphisms that reduce their B12 utilization

Weight Loss Clinical Trial Results In Phase 2 clinical trials: Participants receiving 12 mg experienced up to 24.2% average body weight loss at 48 weeks Additional studies reported up to 28.7% weight reduction at 68 weeks Higher doses (8 mg and 12 mg) demonstrated the most significant results These findings suggest Retatrutide may outperform current GLP-1 therapies and dual-agonist medications in terms of total weight loss

J AnimPhysiolAnimNutr (Berl) (2017) 101(4):60528