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67 kDa, 10 mg/ml BSA + 167.5 g/ml Evans blue) were also tested for permeability

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1 Introduction Ulcerative colitis (UC) is an inflammatory bowel disease characterized by chronic inflammation of the colonic and rectal mucosa ( The pathogenesis of UC is complex, involving the interplay of multiple factors, including genetics, environment, gut microbiota dysbiosis, host metabolic disorders, and immune dysfunction ( Gegen Qinlian Decoction (GQD) is a traditional Chinese medicinal formula clinically employed for treating ulcerative colitis and was first documented in the Treatise on Cold Damage Disorders ( Puerariae Lobatae Radix (Lobed Kudzuvine Root, Gegen), Scutellariae Radix (Baical Skullcap Root, Huangqin), Coptidis Rhizoma (Coptis Root, Huanglian), and Glycyrrhizae Radix et Rhizoma (liquorice root, Gancao) ( T cells are critical regulators of intestinal immunity, with IFN- and IL-17-producing subsets implicated in UC pathogenesis and tissue-resident subsets essential for mucosal repair ( Figure 1 )

Rotating sites consistently prevents the tissue trauma that contributes to reactions