We demonstrated that, at low doses (ng), local (intraplantar) or systemic (intraperitoneal) injections of thymulin resulted in hyperalgesia with an increase in proinflammatory mediators, and that this peptide could act directly on the afferent nerve terminals through prostaglandinE2 (PGE2)dependent mechanisms, thus forming a neuroimmune loop involving capsaicinsensitive primary afferent fibers
It is not approved for human consumption or clinical use
2-8C SMILES string N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O InChI 1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1 InChI key RWSXRVCMGQZWBV-WDSKDSINSA-N General description GSHGSH Application L-GSH-GST S -GSH 5-10 mMS-(GST) Biochem/physiol Actions GSHGSH S- (paradoxical effect) Still not finding the right product
capillary voltage, 4500 V