The results reported a 6.0%, 6.8%, 9.1%, 9.7%, and 10.8% decrease in body weight for the groups receiving cagrilintide in doses of 0.3 mg, 0.6 mg, 1.2 mg, 2.4 mg, and 4.5 mg, respectively [1]
Similarly to BPC-157, TB-500 is banned for use in sport by WADA [7]
Some patients may experience increased appetite or weight regain after stopping treatment
Cagrilintide vs semaglutide (Wegovy/Ozempic) Mechanism: Cagrilintide: Amylin receptor agonist Semaglutide: GLP-1 receptor agonist Different pathways Weight loss: Cagrilintide alone: 10-12% Semaglutide alone: 10-15% Similar efficacy monotherapy Gastric emptying: Cagrilintide: Very strong delay Semaglutide: Moderate delay Cagrilintide more powerful Side effects: Cagrilintide: More GI effects (stronger gastric slowing) Semaglutide: Moderate GI effects Cagrilintide harder to tolerate for some Availability: Cagrilintide: Investigational (not approved) Semaglutide: FDA approved, widely available Semaglutide easier to obtain currently Combination potential: Synergistic together (CagriSema) 15-25% weight loss combined Best of both mechanisms Verdict: Similar monotherapy efficacy, but combine for maximum results
