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The compound's ability to activate multiple pathways simultaneously represents a paradigm shift from earlier single-mechanism approaches

Preclinical animal studies, in vitro mechanistic investigations, and human clinical studies were eligible

Dosage and frequency of B12 depending on the supplement form B12 tablets/capsules Cyanocobalamin: typical supplement values are around 25-100 mcg daily

Jiahui and colleagues reported that a DNAJC subfamily member, T-cell activation inhibitor in mitochondria (TCAIM), provides posttranslational modification and protection to -ketoglutarate dehydrogenase in an HSPA9-dependent manner (Jiahui et al., 2025), revealing a novel mode of mitochondrial chaperoning