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For example, chronic alcohol feeding in diethylnitrosamine (DEN)-induced HCC mice leads to reduced antitumor CD8+ T cells and an increase in tumor-associated macrophages (TAMs), which tend to polarize toward the M2 phenotype after alcohol exposure (89)

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The nitric oxide group is attached to the sulfur atom of the cysteine residue in glutathione

The human body responds to oxidative damage with an antioxidant defense system, including enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and glutathione reductase (GR), as well as vitamin C, vitamin E, Vitamin D, carotenoids and glutathione (GSH)