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27 Together with other age-related modifications of the protein (noted below) and other constituents, these changes result in a less-flexible lens with limited accommodative capability

In an experimental model, transgenic mice expressing a kinase-deficient IGF-1R -subunit (thus displaying reduced signal transduction in both IGF-1R and hybrid receptors) developed diabetes early on life [162, 236]

Historically, -tubulin, the main component of spindle microtubules, has been believed to govern spindle microtubule dynamics during chromosome segregation 21

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