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As a result, surface expression of B2M and class I HLAs is reduced, helping the virus evade identification and clearance of infected cells by cytotoxic CD8+ T cells (138, 158, 159)

The loading dose regimen achieved the quickest and highest increase, reaching a median vitamin B12 concentration of 1090 pmol/L (reference range 350-650 pmol/L) after 14 days

The safety was preliminarily verified: The acute toxicity test showed that a single subcutaneous injection of AOD 9604 (50 mg/kg) did not cause death or obvious toxic reactions in mice

Multi-level anti-inflammatory modulation reduces IL-6, TNF-alpha, and COX-2 expression, dampening the inflammatory response that can delay healing