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Mechanisms of action of intrauterine devices: update and estimation of postfertilization effects

These channels appear to play a role in regulating neuronal excitability and are found in brain regions such as the hippocampus, amygdala, and prefrontal cortex

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Also, autaptic hippocampal cultures produced from these transgenic mice showed a decrease in both amplitude and frequency of EPSCs, whilst neurons of Mecp2 Tg1 mice, with an upregulated Mecp2 gene, had an opposite effect [377]