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They work especially well when combined with GLP-1 medications

The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis (Bays et al., NEJM 2025) reported 28.7% mean weight loss at 68 weeks at the 12 mg dose, plus a 75.8% reduction in WOMAC knee pain scores

Receptor Pharmacology and Signaling Pathways : Characterizing activation of amylin/calcitonin receptors, downstream signaling, and functional readouts in different cell systems

On the alternatives he wants to open up, Kennedy said on a podcast, Youre going to get a lot of charlatans, and youre going to get people who have bad results. He added, You cant prevent that either way. You can, though, at least some of it