Use of growth hormone, IGF-I, and insulin for anabolic purpose: Pharmacological basis, methods of detection, and adverse effects. 2018.
While originally discovered in the 1970s, it has gained renewed interest in clinical and anti-aging circles due to its powerful ability to support skin repair, collagen production, and tissue remodeling at the cellular level
253,279,280 Uric acid can enhance AKT phosphorylation, which subsequently leads to PRAS40 phosphorylation with the activation of mTOR, 281 resulting in the inhibition of autophagy, as well as inhibiting AMPK phosphorylation
This preclinical data provides an excellent base for human safety and efficacy trials [25]