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It is studied for its role in cell motility and differentiation, forming a 1:1 complex with monomeric actin (G-actin) to act as an actin buffer, relevant to laboratory research on cell migration and cell differentiation pathways
Although FOXO4s specific effects on mitochondria are as direct as the other peptides above, it is known to regulate the expression of genes involved in oxidative stress response and energy metabolism, which can impact mitochondrial function indirectly (Liu, 2019)