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this founder deletion occurs primarily in individuals of European descent and likely arose in Germany in approximately 700 AD [10]

Biomed Mater (2025) 20:055014

Development and biological function of the female gonads and genitalia in IGF-I deficiency Laron syndrome as a model

Although comparative studies have showed that Hunner lesions patients are older, 86, 87, 101-103 have greater urinary frequency and nocturia, 86, 87, 102, 103 higher ICSI scores, 86, 87, 103 and lower bladder capacity 101, 103 compared to those without Hunner lesion, cystoscopy remains the only reliable way to diagnose the presence or absence of Hunner lesions given the overlaps in clinical symptomatology