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Inhibition of Rac1 activity in the hippocampus impairs the forgetting of contextual fear memory

It has garnered considerable attention for its remarkable therapeutic potential in various medical conditions, ranging from gastrointestinal disorders to musculoskeletal injuries and beyond

To demonstrate that melatonin supplementation alleviates ovarian oxidative damage by enhancing the H3K18la-STEAP3 axis through metabolic reprogramming and lactate accumulation, we first examined the expression of key glycolysis-related genes, including HK2 , 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase ( PFKFB ), Lactate Dehydrogenase A (LDHA), and blood lactate levels