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Furthermore, it increases intestinal permeability, which makes it more likely for microorganisms and antigens from the luminal environment to enter the bloodstream and increase the risk of systemic reaction syndrome (Trushina and McMurray 2007)

(PubMed) Dangour AD, Allen E, Clarke R, et al

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Its supplementation elevates NAD + , activating SIRT1 to regulate metabolism and suppress neuroinflammation ( 4.5 Limitations and future directions Limitations of the present study include incomplete recapitulation of human SAE heterogeneity by CLP and the lack of Nrf2 knockout/GSH inhibitor validation