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Despite promising findings, gaps in the evidence base, including the need for larger, long-term, and rigorously controlled trials, remain significant barriers to clinical translation

In ferroptosis-sensitive SKOV3 and CAOV3, p53-dependent effects are not observable because APR-246 acts primarily through its induction of ferroptosis

Although generally considered safe, some individuals may experience mild gastrointestinal discomfort or allergic reactions to certain ingredients

It screens for common indoor toxins such as ochratoxin A, aflatoxins, gliotoxin, zearalenone, and trichothecenes , many of which are known to activate mast cells, increase gut permeability, and impair neurological function 29