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Glossary Endoplasmic reticulum-associated degradation (ERAD) A cellular pathway in which newly translated misfolded proteins of the endoplasmic reticulum are ubiquitylated and shuttled into the cytoplasm for proteasomal degradation

Cryo-EM data for the wt PV2-CP17 complex were collected at 300 kV on a Titan Krios (Thermo Fisher Scientific) equipped with a K3 DED and GIF Quantum energy filter (Gatan) at the electron Bio-Imaging Centre, Diamond Light Source, UK