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doi: 10.3389/fimmu.2021.792711 Received 11 October 2021 Accepted 25 November 2021 Published 15 December 2021 Volume 12 - 2021 Edited by Serge Nataf, Universit Claude Bernard Lyon 1, France Reviewed by Pavan Bhargava, Johns Hopkins University, United States

The functional antagonism between Th17 cells and Treg cells primarily manifests in their reciprocal interactions and regulatory mechanisms within the immune system ( Treg cells mainly fall into four categories and use direct or indirect interaction to carry out immunosuppressive actions: 1) Cytokine-mediated suppression: TGF-, IL-10, and IL-35 induce Treg development, prevent antigen-presenting cell (APC) maturation, and mediate bystander suppression ( 3 Metabolic programs governing the Th17/Treg balance Metabolic reprogramming critically controls Th17 and Treg cell fate

Next, we assessed the anti-tumor activity of AP probe-net in vivo, using nude mice for a xenograft study

Cell 7 , 14151426 (2008)