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Its accumulation reflects impaired glutathione regeneration, loss of regulatory control within the -glutamyl cycle, and metabolic conditions that favour diversion of intermediates away from productive glutathione synthesis

Nat Commun (2017) 8:15221

In lipopolysaccharide (LPS)-induced depressive rat models, curcumin pre-treatment reduced neuronal death in the hippocampal CA1 region, likely via the miR-146a-5p/ERK signaling pathway, and was associated with improved synaptic function ( Patients with myocardial infarction (MI) exhibit significantly increased risks of developing depression and anxiety disorders (Sun et al., 2021

Meanwhile, low levels of follicular glutathione are associated with premature ovarian aging and lower fertilization rates