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It is modeled after a protective protein fragment associated with gastric juice and has become a widely studied compound in preclinical research

Supporting may be a dramatic decrease of glutathione levels in the rat brain after a paracetamol oral overdose (3.0 g/kg) (4) and brain tissue susceptibility to oxidative stress (high content of peroxidizable unsaturated fatty acids, high oxygen consumption per unit weight, but poorly developed antioxidative defense mechanisms) (5)

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Ten-to-twelve-month-old beagle dogs weighing between 9.8 and 12.8 kg were purchased from YaDong Experimental Animal Research Centre, Nanjing, China