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Efficacy and safety of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with moderate to severe plaque psoriasis over 52 weeks: a phase III, randomized, controlled trial (ESTEEM 2)

Clinical outcomes from the PARAMEDIC2 trial are summarized, showing higher rates of ROSC in the epinephrine group (36.3%) compared with placebo (11.7%), a modest increase in 30-day survival, but a higher proportion of survivors with severe neurological impairment (31.0% vs

Are there any potential side effects

Simple timing framework Baseline Discuss baseline labs before starting, especially with autoimmune disease, gut symptoms, active injury, infection concern, liver disease, kidney disease, or copper concerns