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PMID: 24384493

Some studies have concurrently employed cerebral blood flow perfusion imaging, revealing that the hypometabolic regions extend beyond those with reduced perfusion, suggesting the presence of intrinsic mitochondrial dysfunction in neurons (165)

Pioglitazone inhibits diabetes-induced atrial mitochondrial oxidative stress and improves mitochondrial biogenesis, dynamics, and function through the PPAR-/PGC-1 signaling pathway

for example, walking may worsen under time pressure but improve when listening to music 15 , tremor may amplify with increased cognitive load 16 , and sudden bursts of rapid movement can occur during emergencies 17