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Morphine was administered via the IV route to rats after arthritis was induced using Freunds adjuvant

Apart from the antioxidant protections, a trial on oral supplementation during the periods of high-intensity exercises also showed benefits in the modulation of inflammatory signaling, the pro- and anti-inflammatory cytokines released, together with a potential pro-angiogenic effect on hematologic parameters such as hemoglobin, red blood cell number, vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF) [74]

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During inflammation, proinflammatory mediators are released to activate immune responses aimed at eliminating injurious agents and initiating tissue healing [27]