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Under its physiological functional state, Prx2 appears as a monomer (active form) of about 2030 kDa and when interacting with H 2 O 2 , Prx2 is oxidized and a disulfide-linked dimmer is formed (inactive form) [73, 77]

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A meta-analysis of 87 studies (9,109 participants) found that ASD children had significantly elevated blood levels of oxidative markers such as GSSG, malondialdehyde, and homocysteine, while significantly decreased levels of GSH, total glutathione, the GSH/GSSG ratio, and antioxidant substances such as cysteine, vitamin B9, and vitamin D