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The PepT1 (SLC15A1) transporter a proton-coupled oligopeptide transporter normally expressed in the small intestine is dramatically upregulated in the colon during inflammatory bowel disease

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Bean J, Brennan C, Shih J-Y, Riely G, Viale A, Wang L, Chitale D, Motoi N, Szoke J, Broderick S, Balak M, Chang W-C, Yu C-J, Gazdar A, Pass H, Rusch V, Gerald W, Huang S-F, Yang P-C, Miller V, Ladanyi M, Yang C-H and Pao W (2007) MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib

Think of it like watering a plant: an injection is like getting water straight to the roots, guaranteeing it gets where it needs to go