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While Alnylams Phase III APOLLO-B study hit both key primary and secondary endpoints, the FDA stated in the documents that the effects of patisiran compared to placebo on both endpoints were small, of questionable clinical meaningfulness, and may not be detectable by patients. Major discussion points during the adcomm meeting included whether these key endpoints were appropriate to ascertain clinical meaningfulness in the ATTR-CM population, and panelists expressed varying opinions on whether the magnitude of the benefit seen in trial data was clinically meaningful

On the other hand, IV therapy for general wellness or lifestyle purposes is almost never covered

Zone 2 is the kind of effort you can sustain for a long time

Finally, try not to depend too much on antacids: If you need magnesium-based (or any type of) antacids for more than two weeks, tell your doctor 18