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However, regardless of their definite positive effects, therapeutic applications of natural neurotrophins like NGF and BDNF, for treatment of neurodegenerative diseases, are limited due to their inability to cross blood brain barrier and also susceptibility to degradation by peripheral peptidases (Tomioka et al., 2014)

the subject in need thereof may be a subject identified as being particularly responsive to treatment according to the methods described herein, i.e

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Many do not, because the compound quality is unverified, the dose is based on internet research rather than clinical assessment, and there is no baseline, no follow-up, and no protocol adjustment based on individual response