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In addition, IF has been shown to modulate the limbic dopaminergic and thyrotropin-releasing hormone (TRH) systems, which regulate feeding behavior and hypothalamic-pituitary-thyroid (HPT) axis activity [62]

In vitro experiments have shown that paeoniflorin can upregulate the expression levels of SLC7A11, thereby inhibiting ferroptosis in renal tubular epithelial cells, providing a potential therapeutic strategy for protecting kidney tissues (182)

Ubiquitination and deubiquitination affect intracellular protein homeostasis by altering the ubiquitin chain of substrate proteins, influencing their degradation by the proteasome, and modulating downstream signaling pathways

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